Endocrine Abstracts

Introduction: Cells of the neuroendocrine system are spread throughout the body, and they can give rise to various neuroendocrine tumors with unpredictable evolution. It has been observed that they are often associated with the development of fibrosis, both local and distant.Case presentation: We present the case of an 81 year-old, normal-weight woman, who firstly presented in our clinic in 2014 for multinodular goiter (normal calcitonin). Fine needle as...

Background: Iatrogeny is the most common cause of Cushing syndrome (CS), with most reported cases due to prolonged use of oral, parenteral or, rarely, topical corticosteroid preparations. Few cases of CS (and consecutive adrenal insufficiency (AI)) due to intranasal corticoids have been reported and the vast majority were documented in pediatric patients.Case reports: We present two cases of iatrogenic CS due to chronic intranasal administration of over-...

Background: Surgery is the standard treatment in patients with medullary thyroid carcinoma (MTC), 43% being biochemically cured postoperative in a large series, the most important prognostic factor being the stage of the disease.Material and methods: We present 3 cases of biochemical cured patients after surgery with different preoperative presentation. Calcitonin and carcinoembryonic antigen (CEA) were measured by chemiluminescence. Histological examina...

Background: Prevalence and type of amiodarone-induced thyroid dysfunction in a population depend on geographical iodine intake.Aims: To assess differences in amiodarone-induced thyrotoxicosis pattern before and after iodine supplementation.Patients and methods: 84 patients (41M/43F) with amiodarone-induced thyrotoxicosis, aged 60.1±11.9 years, were retrospectively reviewed. 28 patients were resident in former iodine-deficient ...

Proton nuclear magnetic resonance spectroscopy (1H-NMR) was applied to investigate metabolic profile of type 2 diabetes mellitus (T2DM) patients and identify possible disorders of T2DM.We investigate the potential relationship between diabetic retinopathy (DR), diabetic neuropathy (DN), estimated glomerular filtration rate (eGFR), anthropometric indicators (body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), waist to sta...

Turner Syndrome (TS) is defined as the combination of characteristic physical features in phenotypic females and complete or partial absence of the second sex chromosome. Short stature is a constant clinical finding in patients with TS. We report the case of a 18 year old female with TS and normal stature. Primary amenorrhea was the reason for the first clinical presentation. Laboratory evaluation showed hypergonadotropic hypogonadism, low oestrogens and testosterone. A pelvic...

Introduction: Primary adrenal insufficiency (PAI) is a rare disease with a prevalence of 82–144 cases/milion. The etiology of PAI is represented primarily by autoimmune adrenalitis, followed by tuberculosis and less common by fungal infections, HIV, hemorrage in adrenal glands, certain drugs and by some genetic disorders such as Triple A syndrome (AAA), Adrenoleukodystrophy (ALD), congenital adrenal hypoplasia, congenital adrenal hyperplasia, etc.C...

Human adipose tissue provides abundant source of mesenchymal stem cells, which can be easily and safely harvested as compared with human bone marrow.The aim of this study was to differentiate a viable osteoblast and adipocyte cell culture from mesenchymal stem cells, an experimental model to study the interrelation between adipocytes and bone forming cells, osteoblasts.Materials and methods: Subcutaneous adipose tissue liposuction ...

We present an experimental study on human prolactinoma in cell culture from a patient that partially responded to cabergoline treatment and had to have surgical treatment.Aim: The aim of the study was to assess the effect of cabergoline, dopamine and melatonin on prolactin secretion and cell proliferation in human prolactinoma cell culture from a patient that had transsphenoidal surgery.Material and methods: Tissue specimen derived...

Introduction: Elastography is a new dynamic technique that uses ultrasonography for the assessment of tissue stiffness. The principle of ultrasound-elastography is that compression of the examined tissue induces a smaller strain in hard tissues than in soft ones. Until now elastography has been applied to study the hardness and elasticity of thyroid nodules, aiming to differentiate malignant from benign ones.Aim: We decided to study if ultrasound elastog...